Literature summary extracted from

Lv, B.; Xie, F.; Zhao, P.; Ma, X.; Jiang, W.; Yu, J.; Zhang, X.; Jia, J.
Promotion of cellular growth and motility is independent of enzymatic activity of fibroblast activation protein-alpha (2016), Cancer Genomics Proteomics, 13, 201-208 .

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.B28	membrane	integral membrane protein	Homo sapiens	16020	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B28	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B28	BT-549 cell	-	Homo sapiens	-
3.4.21.B28	fibroblast	expressed in most stromal fibroblasts	Homo sapiens	-
3.4.21.B28	MCF-7 cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B28	FAPalpha	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.21.B28	physiological function	the enzyme promotes cell growth, adhesion, invasion and migration in breast cancer. Its regulatory effects are independent of its enzymatic activity. The PI3K/AKT and MMP2/9 signaling pathway might be involved in the effects of FAPalpha on breast cancer cells	Homo sapiens

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Release 2023.1 (January 2023)